Nishikori needed six match points to seal the win in two hours at the ATP Masters event held behind closed doors at the Foro Italico.
The withdrawal of Osaka meant that two of the current world's top three women's players would not play at Roland Garros this year, as reigning champion and world No. 1 Ashleigh Barty already announced earlier this month that she would not be able to participate the clay major due to the COVID-19 pandemic.
Stage One involves 32 groups of four players, with the player who tops each group progressing to Stage Two.
The Israeli club scored the first goal in the 50th minute, with a successful penalty kick by midfielder Dan Biton, after the visitors' captain Syarhey Kislyak pushed Maccabi's Dor Peretz in the penalty area.
Jota has agreed to a five-year deal with Liverpool and the move is likely to be completed as soon as the 23-year-old completes his medical check.
Bayern chairman Karl-Heinz Rummenigge sees BVB as being the club's most dangerous rivals this season. "They have had a much longer break and preparation," the 64-year-old said.
Serginho then turned from hero to villain when he received a second yellow card for scything down Carlos Eduardo two minutes from time.
Brazil has reported more than 135,000 COVID-19 deaths and over 4,497,000 confirmed cases of the virus. Enditem
Maccabi almost doubled the lead in the 75th minute, but defender Ofir Davidzada missed an easy opportunity, five meters from an empty net.
It showed that in 56 percent of the incidents, perpetrators employed anti-Chinese hate speech, and that even though adults were present in almost half of the incidents, bystanders intervened in only 10 percent of the cases. Enditem
The 33-year-old Serb now faces a semifinal against Casper Ruud of Norway, who beat fourth seed Matteo Berrettini of Italy 4-6, 6-3, 7-6 (5).